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Brain Diseases and Hydrogen Therapy

How does Hydrogen Therapy assist with Parkinson’s and Brain diseases?

Parkinson’s is a nerve disease that is caused by the lack of dopamine in the brain. Major symptoms include shaking of hands and feet, slower movement, muscle stiffness and it might also develop dementia as complication. Symptoms arise the most around the age after 40s~50s, and it is categorized as an incurable disease. Researches have been happening in Japan and USA to study whether molecular hydrogen, a strong anti-oxidant, has the ability to supress progression of Parkinson’s and other brain diseases. This page organizes some important research papers on the relationship of hydrogen and Parkinson’s/brain diseases. (Source: We hope that it will help Parkinson’s/brain disease patients and their families.

Ingestion of hydrogen gas can improve neurological function outcome in the spontaneously hypertensive stroke

Hydrogen gas decreased oxidative stress (8-OHdG, 4-HNE and nitrotyrosine) and exerted neuroprotective effects (improvement of neurological score and reduction in infarct and hemorrhagic volumes) and also reduced MMP-9 activation in a middle cerebral artery occlusion model.

Medical hydrogen gas for stroke therapy: summary of progress 2015-2016

Stroke is a cerebrovascular disease with high mortality and morbidity. Despite extensive research, there are only a very limited number of therapeutic approaches suitable for treatment of stroke patients as yet. Mounting evidence has demonstrated that such gases as oxygen, hydrogen and hydrogen sulfide are able to provide neuroprotection after stroke. (Discipline of Neuroscience, Department of Anatomy, Shanghai Jia Tong University School of Medicine Jun 30th, 2017)

Hydrogen gas inhalation treatment in acute cerebral infarction: a randomized controlled clinical study on safety and neuroprotection

Molecular hydrogen (H2) acts as a therapeutic antioxidant. Inhalation of H2gas (1-4%) was effective for the improvement of cerebral infarction in multiple animal experiments. The H2 group showed no significant adverse effects with improvements in oxygen saturation. H2 treatment was safe and effective in patients with acute cerebral infarction. These results suggested a potential for widespread and general application of H2 gas. (Department of Neurosurgery, Nishijima Hospital, Numazu-city, Shizuoka-ken, Japan Jun 29th, 2017)

Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis (a.k.a Mitochondrial Hormesis)

Inhalation of molecular hydrogen (H2) gas ameliorates oxidative stress-induced acute injuries in the brain. It prevents chronic neurodegenerative diseases including Parkinson’s disease in animal and clinical studies. (Tokyo Metropolitan Institute of Gerontology, May 3rd, 2017)

Dementia treatment with Hydrogen Gas Inhalation

Brain disease is introduced due to damage of brain tissues and cell damage, which is basically induced by oxidative stress. Neurodegenerative diseases are divided into two types: one impacting movement, such as cerebellar ataxia, and the other affecting memory and is related to dementia. Study found that inhaling molecular hydrogen deter the decline of memory and learning ability. (Department of Neurosurgery & Brain and nerve Research Laboratory, the first affiliated hospital of Soochow university, Suzhou, Jiangsu Province, China)


Anti-inflammatory and antitumor action of hydrogen via reactive oxygen species
Hydrogen (H2) has advantages that lead it to be used as a novel antioxidant in preventive and therapeutic applications. H2 selectively reduces oxidants of the detrimental reactive oxygen species (ROS), including hydroxyl radicals (·OH) and peroxynitrite (ONOO−), which serve a causative role in the promotion of tumor cell proliferation, invasion and metastasis. (Tianjin University School of Medicine General Hospital, June 26th 2018)

Hydrogen as protective agent against radiation side effects

Molecular hydrogen (H2) has antioxidant activities by selectively reducing ·OH and peroxynitrite(ONOO-). The study first hypothesized and demonstrated the radioprotective effect of H2 in vitro and in vivo. It was also then used in clinic to improve the survival rate of patients treated with radiotherapy for liver tumor. (Navy General Hospital, Fucheng Road, Beijing, China, Sept 14th, 2013)

Recent Progress toward hydrogen medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications

Continuous oxidative stress is one of the major causes of cancer and the aging process. The study determined that molecular hydrogen (H2) has a potential as an antioxidant in preventive and therapeutic purposes. (Department of Biochemistry and Cell biology, Graduate School of Medicine, Nakahara-ku, Kosugi-machi, Japan)

Hydrogen Gas effect improves immunity of cancer patients

It has been reported that PD-1-expressing CD8+ T cells in the peripheral blood of cancer patients are associated with poor cancer prognosis. Results of this study suggest that hydrogen gas improves the prognosis of cancer patients by reducing the proportion of terminal PD-1+ CD8+ T cells. (Tamana Regional Health Medical Center, Japan, October 2018)

Hydrogen acts as a therapeutic antioxidant by reducing cytotoxic oxygen radicals

Persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. This study show that hydrogen (H2) has potential as an antioxidant in preventive and therapeutic applications. (Department of Biochemistry and Cell biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Japan, May 7th 2007)

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